Map & Directions

Well located in the Owensboro South area, our Hampton Inn by Hilton Owensboro South is within a few miles from Downtown Owensboro, Owensboro Convention Center, Smothers Park and Owensboro-Daviess County Airport.

Our location places you within a short distance of a wide variety of shopping stores and restaurants. With a variety of restaurants nearby you can dine at Texas Roadhouse, Fuji of Japan, Buffalo Wild Wings, Olive Garden, Applebee's, TGI Fridays and O'Charley's Restaurant & Bar; and for a quick bite you'll find the Taco Bell, White Castle, Chick-fill-A, Denny's, McDonald's and Panera Bread.

Our elegantly appointed hotel offers 86 professionally decorated guestrooms and suites only minutes from Downtown Owensboro, Owensboro's charming downtown, and easy accessibility to major highways in Owensboro including 60. Heading 60 West to Owensboro-Daviess County Airport or 60 East to Fort Knox, an Army training facility and home to the Patton Museum (open to the public); and Hwy 431 (Frederica St.) takes you direct to Owensboro Convention Center.


The Hampton Inn by Hilton Owensboro South hotel is located at 615 Salem Dr, Owensboro, KY 42303

  • From I-60 East/West: Exit 14 off Hwy 60 By-Pass, go South on Hwy 431 (Frederica St.), turn left onto Salem Drive--between Wendy's and Chick-Fil-A, hotel is located on the left.
  • From Downtown Owensboro and Owensboro Convention Center: Go South on Hwy 431 (Frederica St.), turn left onto Salem Drive--between Wendy's and Chick-Fil-A, hotel is located on the left.
  • From Owensboro-Daviess County Airport (3 miles): Turn left from airport to Parish Ave. To the right, exit to 60. Pass exit #14.
  • Evansville Regional Airport (46 miles): Keep left toward Bussing Dr (0.2 mi.), bear left onto Bussing Dr (0.2 mi.), turn left onto IN-57 (0.8 mi.), turn left onto US-41 S (16.2 mi.), keep straight onto Pennyrile Pkwy (0.8 mi.), at exit 77, take ramp right for Audubon Parkway East toward Owensboro (23.8 mi.), at exit 24A, take ramp right for Owensboro toward William H Natcher Parkway East (3.5 mi.), at exit 14, take ramp right for US-431 toward Livermore / Owensboro (0.3 mi.), turn right onto US-431 S / Frederica St (0.1 mi.), turn left onto Salem Dr (0.2 mi.) and you will arrive at Salem Dr on the left (0.0 mi.)